Understanding how cell division mistakes lead to human disorders

Imaging technology supplied by Image Solutions (UK) Ltd (Imsol) is helping scientists at the University of Sussex’s Centre for Genome Damage and Stability (CGDS) to get a better understanding of how mistakes made during the process of cell division can lead to disorders and diseases within humans.

The CGDS houses 16 research groups, all focused on different aspects of DNA damage responses and genome instability. One of the groups, managed by Wellcome Trust Senior Fellow Dr Helfrid Hochegger, uses Imsol’s DeltaVision Core and Personal DV imaging systems in order to better understand the activities of enzymes known as kinases. Successful cell separation depends on kinase activity and as a result they are one of the most studied of all enzyme families.