Tuesday, 11 January 2011
Controlled ice nucleation for freeze drying scale-up
Chaired by Professor Michael J Pikal, Professor and Distinguished Chair, Pharmaceutical Technology at the University of Connecticut - the scope of the 27th January 2011 webinar will be to discuss controlled ice nucleation by both the ice-fog technique and the depressurization technique and to review the advantages of controlled ice nucleation.
To practice "Quality by Design", organizations must be able to scale up freeze drying results generated in the laboratory to full scale manufacturing. To do this a technique must address a number of heat and mass transfer scale up issues. The 27th January webinar will suggest methodology for estimating the changes to a laboratory procedure that are required.
In addition the webinar will address the scale-up challenge presented by the difference in ice nucleation temperatures between the laboratory and the Class 100 environment found in manufacturing. Much greater degrees of super-cooling are typically found in manufacturing, meaning manufacturing processes run longer and run hotter than in the laboratory. Operators may minimize the freezing difference between laboratory and manufacturing by annealing in the frozen state, but perhaps the best strategy is to control the ice nucleation temperature. In this webinar the author discusses controlled ice nucleation by both the ice-fog technique and the depressurization technique and reviews the advantages of controlled ice nucleation.
To register for the January 27, 2011 webinar, visit www.spscientific.com/LyoTech-Center/LyoLearn-Webinars.aspx